Efficacy of Ketogenic Diet, Modified Atkins Diet, and Low Glycemic Index Therapy Diet Among Children With Drug-Resistant Epilepsy: A Randomized Clinical Trial.

ABSTRACT:

Importance

The ketogenic diet (KD) has been used successfully to treat children with drug-resistant epilepsy. Data assessing the efficacy of the modified Atkins diet (MAD) and low glycemic index therapy (LGIT) diet compared with the KD are scarce.

Objective

To determine whether the MAD and LGIT diet are noninferior to the KD among children with drug-resistant epilepsy.

Design, setting, and participants

One hundred seventy children aged between 1 and 15 years who had 4 or more seizures per month, had not responded to 2 or more antiseizure drugs, and had not been treated previously with the KD, MAD, or LGIT diet were enrolled between April 1, 2016, and August 20, 2017, at a tertiary care referral center in India.

Exposures

Children were randomly assigned to recei

SUBMITTER: Sondhi V 

PROVIDER: S-EPMC7400196 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature