FimH and Anti-Adhesive Therapeutics: A Disarming Strategy Against Uropathogens.

ABSTRACT: Chaperone-usher fimbrial adhesins are powerful weapons against the uropathogens that allow the establishment of urinary tract infections (UTIs). As the antibiotic therapeutic strategy has become less effective in the treatment of uropathogen-related UTIs, the anti-adhesive molecules active against fimbrial adhesins, key determinants of urovirulence, are attractive alternatives. The best-characterized bacterial adhesin is FimH, produced by uropathogenic Escherichia coli (UPEC). Hence, a number of high-affinity mono- and polyvalent mannose-based FimH antagonists, characterized by different bioavailabilities, have been reported. Given that antagonist affinities are firmly associated with the functional heterogeneities of different FimH variants, several FimH inhibitors have been developed usi

SUBMITTER: Sarshar M 

PROVIDER: S-EPMC7400442 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature