Frequent Recombination Events in Leishmania donovani: Mining Population Data.

ABSTRACT: The Leishmania donovani species complex consists of all L. donovani and L. infantum strains mainly responsible for visceral leishmaniasis (VL). It was suggested that genome rearrangements in Leishmania spp. occur very often, thus enabling parasites to adapt to the different environmental conditions. Some of these rearrangements may be directly linked to the virulence or explain the reduced efficacy of antimonial drugs in some isolates. In the current study, we focused on a large-scale analysis of putative gene conversion events using publicly available datasets. Previous population study of L. donovani suggested that population variability of L. donovani is relatively low, however the authors used masking procedures and strict read selection criter

SUBMITTER: Rogozin IB 

PROVIDER: S-EPMC7400496 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature