Ontology highlight
ABSTRACT:
SUBMITTER: Li T
PROVIDER: S-EPMC7400510 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Communications biology 20200803 1
MucA and MucB are critical negative modulators of sigma factor AlgU and regulate the mucoid conversion of Pseudomonas aeruginosa. Previous studies have revealed that lipid signals antagonize MucA-MucB binding. Here we report the crystal structure of MucB in complex with the periplasmic domain of MucA and polyethylene glycol (PEG), which unveiled an intermediate state preceding the MucA-MucB dissociation. Based on the biochemical experiments, the aliphatic side chain with a polar group was found ...[more]