The WWOX gene in brain development and pathology.

ABSTRACT:

Impact statement

WW domain-containing oxidoreductase encoded by the WWOX gene is a transcription regulator and a key player in a number of cellular and biological processes such as tumor suppression, cell proliferation, apoptosis induction, steroid metabolism, and central nervous system development. This review provides a comprehensive summary of currently known roles and discusses the importance of WWOX gene for CNS development and functioning.

SUBMITTER: Kosla K 

PROVIDER: S-EPMC7400721 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature