The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with poor prognosis and high rates of relapse. The lack of actionable targets for TNBC has contributed to the high mortality rates of this disease, and new candidate molecules for potential manipulation are urgently required. Here, we show that macrophage-stimulating protein (MSP) and its tyrosine kinase receptor, Recepteur d'origine nantais (RON), are potent drivers of cancer cell growth and tumor progression in a mouse model of TNBC driven by the loss of Trp53 and Brca1. After comparison of two genetically engineered mouse models of TNBC, we found that mammary tumors from K14-Cre;Brca1^F/F ;Trp53^F/F (KB1P) mice exhibit high endogenous levels of MSP and RON expression. We show that MS

SUBMITTER: Millar R 

PROVIDER: S-EPMC7400785 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature