MicroRNA-744/transforming growth factor β1 relationship regulates liver cirrhosis.

ABSTRACT:

Background

MicroRNAs have added a new dimension to our understanding of liver cirrhosis (LC) and associated processes like the activation of hepatic stellate cells (HSCs).

Methods

Serum samples were collected from 40 LC patients and 30 healthy donors. CCl₄-induced LC mouse model in vivo and in vitro human HSC LX-2 and murine HSC JS-1 cells were researched.

Results

The levels of serum microRNA (miR)-744 is inversely correlated with the severity of LC and is a reliable biomarker of LC. In CCl₄-induced LC model, the abundance of miR-744 was reduced in both sera and livers compared with sham controls. Importantly, increasing miR-744 abundance with synthetic miR-744 Agomir alleviated liver fibrosis, a critical component of LC, while reducing miR-744 w

SUBMITTER: Ren S 

PROVIDER: S-EPMC7400990 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature