Association between polymorphisms in mannose-binding lectin 2 gene with pulmonary tuberculosis susceptibility.

ABSTRACT:

Background

Mannose-binding lectin (MBL2) is considered to play a role in the human innate immune response to tuberculosis (TB) infections, and 4 common single nucleotide polymorphisms (SNPs) may be associated with pulmonary tuberculosis (PTB) risk. To examine these potential associations, we performed a comprehensive analysis to assess the relationships between MBL2 polymorphisms and PTB.

Methods

The PubMed, Embase, and SinoMed databases were searched for articles published prior to June 13, 2019. Odds ratios with 95% confidence intervals were calculated to evaluate the strength of the relationships.

Results

There were 37 case-control studies examining the effects of the four SNPs in MBL2 on PTB. A positive association between rs11003125 and PTB risk was observed in t

SUBMITTER: Shen W 

PROVIDER: S-EPMC7401221 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature