Combined Treatment of Heteronemin and Tetrac Induces Antiproliferation in Oral Cancer Cells.

ABSTRACT: Heteronemin, a marine sesterterpenoid-type natural product, possesses an antiproliferative effect in cancer cells. In addition, heteronemin has been shown to inhibit p53 expression. Our laboratory has demonstrated that the thyroid hormone deaminated analogue, tetrac, activates p53 and induces antiproliferation in colorectal cancer. However, such drug mechanisms are still to be studied in oral cancer cells. We investigated the antiproliferative effects by Cell Counting Kit-8 and flow cytometry. The signal transduction pathway was measured by Western blotting analyses. Quantitative PCR was used to evaluate gene expression regulated by heteronemin, 3,3',5,5'-tetraiodothyroacetic acid (tetrac), or their combined treatment in oral cancer cells. Heteronemin inhibited not only expression of proli

SUBMITTER: Huang CH 

PROVIDER: S-EPMC7401260 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature