Testis-specific serine kinase protein family in male fertility and as targets for non-hormonal male contraception†.

ABSTRACT: Male contraception is a very active area of research. Several hormonal agents have entered clinical trials, while potential non-hormonal targets have been brought to light more recently and are at earlier stages of development. The general strategy is to target genes along the molecular pathways of sperm production, maturation, or function, and it is predicted that these novel approaches will hopefully lead to more selective male contraceptive compounds with a decreased side effect burden. Protein kinases are known to play a major role in signaling events associated with sperm differentiation and function. In this review, we focus our analysis on the testis-specific serine kinase (TSSK) protein family. We have previously shown that members of the family of TSSKs are postmeiotically express

SUBMITTER: Salicioni AM 

PROVIDER: S-EPMC7401350 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature