Transcriptomic Analysis of the Developmental Similarities and Differences Between the Native Retina and Retinal Organoids.

ABSTRACT:

Purpose

We performed a bioinformatic transcriptome analysis to determine the alteration of gene expression between the native retina and retinal organoids in both mice and humans.

Methods

The datasets of mouse native retina (GSE101986), mouse retinal organoids (GSE102794), human native retina (GSE104827), and human retinal organoids (GSE119320) were obtained from Gene Expression Omnibus. After normalization, a principal component analysis was performed to categorize the samples. The genes were clustered to classify them. A functional analysis was performed using the bioinformatics tool Gene ontology enrichment to analyze the biological processes of selected genes and cellular components.

Results

The development of retinal organoids is slower than that in the native re

SUBMITTER: Cui Z 

PROVIDER: S-EPMC7401421 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature