Age-Related Changes to the Three-Dimensional Full Shape of the Isolated Human Crystalline Lens.

ABSTRACT: Purpose:Studying the full shape crystalline lens geometry is important to understand the changes undergone by the crystalline lens leading to presbyopia, cataract, or failure of emmetropization, and to aid in the design and selection of intraocular lenses and new strategies for correction. We used custom-developed three-dimensional (3-D) quantitative optical coherence tomography (OCT) to study age-related changes in the full shape of the isolated human crystalline lens. Methods:A total of 103 ex vivo human isolated lenses from 87 subjects (age range, 0-56 years) were imaged using a 3-D spectral-domain OCT system. Lens models, constructed after segmentation of the surfaces and distortion correction, were used to automatically quantify central geometric parameters (lens thickness, radii of c

SUBMITTER: Martinez-Enriquez E 

PROVIDER: S-EPMC7401430 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature