Ontology highlight
ABSTRACT:
SUBMITTER: Ai LQ
PROVIDER: S-EPMC7401846 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Investigative ophthalmology & visual science 20200401 4
<h4>Purpose</h4>Purpose The role of endothelial Yes-associated protein 1 (YAP) in the pathogenesis of retinal angiogenesis and the astrocyte network in the mouse oxygen-induced retinopathy (OIR) model is unknown.<h4>Methods</h4>For in vivo studies, OIR was induced in conditional endothelial YAP knockout mice and their wild-type littermates. Retinal vascularization and the astrocyte network were evaluated by whole-mount fluorescence and Western blotting. In vitro experiments were performed in ast ...[more]