Ventricular stroke work and vascular impedance refine the characterization of patients with aortic stenosis.

ABSTRACT: Aortic stenosis (AS) management is classically guided by symptoms and valvular metrics. However, the natural history of AS is dictated by coupling of the left ventricle, aortic valve, and vascular system. We investigated whether metrics of ventricular and vascular state add to the appreciation of AS state above valve gradient alone. Seventy patients with severe symptomatic AS were prospectively followed from baseline to 30 days after transcatheter aortic valve replacement (TAVR). Quality of life (QOL) was assessed using the Kansas City Cardiomyopathy Questionnaire. Left ventricular stroke work (SW_LV) and vascular impedance spectrums were calculated noninvasively using in-house models based on central blood pressure waveforms, along with hemodynamic parameters from echocardiogram

SUBMITTER: Ben-Assa E 

PROVIDER: S-EPMC7401937 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature