Role of Multidrug Resistance Proteins in Nonresponders to Immunomodulatory Therapy for Noninfectious Uveitis.

ABSTRACT:

Purpose

Nearly a third to half of patients with noninfectious uveitis (NIU) fail to achieve control with immunomodulatory therapy (IMT). Multidrug resistance (MDR) proteins are transmembrane proteins that allow efflux of intracellular drugs, leading to drug resistance. The aim of our study was to compare MDR protein function in blood CD4⁺ cells between responders and nonresponders to IMT.

Methods

We included NIU patients on IMT for ≥6 months and corticosteroid dose ≤10 mg/d. Nonresponders to treatment were those with worsening (two or more steps) of inflammation in the past 3 months on full-dose immunosuppressive therapy. MDR function was assessed by Rhodamine-123 dye retention in blood CD4⁺ cells. Three nonresponders were treated with adjunctive oral c

SUBMITTER: Tagirasa R 

PROVIDER: S-EPMC7401954 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature