Upregulation of Tolerogenic Pathways by the Hydrogen Sulfide Donor GYY4137 and Impaired Expression of H₂S-Producing Enzymes in Multiple Sclerosis.

ABSTRACT: The aim of this study was to examine the in vitro effects of the slow-releasing H₂S donor GYY4137 on the immune cells involved in the pathogenesis of the central nervous system (CNS) autoimmune disease, multiple sclerosis (MS). GYY4137 specifically potentiated TGF-β expression and production in dendritic cells and significantly reduced IFN-γ and IL-17 production in the lymph node and spinal cord T cells obtained from mice immunized with CNS antigens. Both the proportion of FoxP3⁺ regulatory CD4⁺ T cells in the lymph node cells, and the percentage of IL-17⁺ CD4⁺ T cells in the spinal cord cells were reduced upon culturing with GYY4137. Interestingly, the peripheral blood mononuclear cells obtained from the MS patients had a lower expres

SUBMITTER: Lazarevic M 

PROVIDER: S-EPMC7402185 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature