Gene expression and cell identity controlled by anaphase-promoting complex.

ABSTRACT: Metazoan development requires the robust proliferation of progenitor cells, the identities of which are established by tightly controlled transcriptional networks¹. As gene expression is globally inhibited during mitosis, the transcriptional programs that define cell identity must be restarted in each cell cycle^2-5 but how this is accomplished is poorly understood. Here we identify a ubiquitin-dependent mechanism that integrates gene expression with cell division to preserve cell identity. We found that WDR5 and TBP, which bind active interphase promoters^6,7, recruit the anaphase-promoting complex (APC/C) to specific transcription start sites during mitosis. This allows APC/C to decorate histones with ubiquitin chains branched at Lys11 and Lys48 (K11/K48-br

SUBMITTER: Oh E 

PROVIDER: S-EPMC7402266 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature