DAnkrd49 and Bdbt act via Casein kinase Iε to regulate planar polarity in Drosophila.

ABSTRACT: The core planar polarity proteins are essential mediators of tissue morphogenesis, controlling both the polarised production of cellular structures and polarised tissue movements. During development the core proteins promote planar polarisation by becoming asymmetrically localised to opposite cell edges within epithelial tissues, forming intercellular protein complexes that coordinate polarity between adjacent cells. Here we describe a novel protein complex that regulates the asymmetric localisation of the core proteins in the Drosophila pupal wing. DAnkrd49 (an ankyrin repeat protein) and Bride of Doubletime (Bdbt, a non-canonical FK506 binding protein family member) physically interact, and regulate each other's levels in vivo. Loss of either protein results in a reduction in core protei

SUBMITTER: Strutt H 

PROVIDER: S-EPMC7402468 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature