Iron deposition in autopsied liver specimens from older patients receiving intravenous iron infusion.

ABSTRACT:

Background

Vitamins and minerals are routinely administered by total parenteral nutrition (TPN). However, in Japan, adjustments in iron dosage are difficult because blended mineral preparations are often used. It is therefore unclear whether the iron content is appropriate in cases of long-term TPN. The aim of the study was to assess the influence of iron administration by long-term TPN on iron deposition in post-mortem liver samples isolated from older deceased patients.

Methods

Liver tissues were collected from post-mortem autopsies of 187 patients over a period of 15 years. Samples were stained with Prussian blue and histologically evaluated from Grade 0-V by at least three different observers. Specimens with positive and negative iron staining were compared, and positive

SUBMITTER: Akatsu H 

PROVIDER: S-EPMC7402501 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature