Modifications of sodium channel voltage dependence induce arrhythmia-favouring dynamics of cardiac action potentials.

ABSTRACT: Heart arrhythmia is a pathological condition where the sequence of electrical impulses in the heart deviates from the normal rhythm. It is often associated with specific channelopathies in cardiac tissue, yet how precisely the changes in ionic channels affect the electrical activity of cardiac cells is still an open question. Even though sodium channel mutations that underlie cardiac syndromes like the Long-Q-T and the Brugada-syndrome are known to affect a number of channel parameters simultaneously, previous studies have predominantly focused on the persistent late component of the sodium current as the causal explanation for an increased risk of heart arrhythmias in these cardiac syndromes. A systematic analysis of the impact of other important sodium channel parameters is currently lac

SUBMITTER: Rose P 

PROVIDER: S-EPMC7402508 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature