Alterations in the fecal microbiota of patients with spinal cord injury.

ABSTRACT:

Objectives

Spinal cord injury (SCI) is associated with severe autonomic dysfunction. Patients with SCI often suffer from a lack of central nervous system control over the gastrointestinal system. Therefore, we hypothesized that patients with SCI would cause intestinal flora imbalance. We investigated alterations in the fecal microbiome in a group of patients with SCI.

Methods

Microbial communities in the feces of 23 patients and 23 healthy controls were investigated using high-throughput Illumina Miseq sequencing targeting the V3-V4 region of the 16S ribosomal RNA (rRNA) gene. The relative abundances between the fecal microbiota at the genus level in patients with SCI and healthy individuals were determined using cluster analysis.

Results

The structure and quantity of

SUBMITTER: Lin R 

PROVIDER: S-EPMC7402510 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature