The location of the axon initial segment affects the bandwidth of spike initiation dynamics.

ABSTRACT: The dynamics and the sharp onset of action potential (AP) generation have recently been the subject of intense experimental and theoretical investigations. According to the resistive coupling theory, an electrotonic interplay between the site of AP initiation in the axon and the somato-dendritic load determines the AP waveform. This phenomenon not only alters the shape of APs recorded at the soma, but also determines the dynamics of excitability across a variety of time scales. Supporting this statement, here we generalize a previous numerical study and extend it to the quantification of the input-output gain of the neuronal dynamical response. We consider three classes of multicompartmental mathematical models, ranging from ball-and-stick simplified descriptions of neuronal excitability t

SUBMITTER: Verbist C 

PROVIDER: S-EPMC7402515 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature