Analyzing the 3D chromatin organization coordinating with gene expression regulation in B-cell lymphoma.

ABSTRACT:

Background

Eukaryotes compact chromosomes densely and non-randomly, forming three-dimensional structures. Alterations of the chromatin structures are often associated with diseases. In particular, aggressive cancer development from the disruption of the humoral immune system presents abnormal gene regulation which is accompanied by chromatin reorganizations. How the chromatin structures orchestrate the gene expression regulation is still poorly understood. Herein, we focus on chromatin dynamics in normal and abnormal B cell lymphocytes, and investigate its functional impact on the regulation of gene expression.

Methods

We conducted an integrative analysis using publicly available multi-omics data that include Hi-C, RNA-seq and ChIP-seq experiments with normal B cells, lympho

SUBMITTER: Nagai LAE 

PROVIDER: S-EPMC7402584 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature