Optimizing management of advanced urothelial carcinoma: A review of emerging therapies and biomarker-driven patient selection.

ABSTRACT:

Introduction

Advanced urothelial carcinoma has been challenging to treat due to limited treatment options, poor response rates, and poor long-term survival. New treatment options hold the promise of improved outcomes for these patients.

Methods

A multidisciplinary working group drafted a management algorithm for advanced urothelial carcinoma using "consensus development conference" methodology. A targeted literature search identified new and emerging treatments for inclusion in the management algorithm. Published clinical data were considered during the algorithm development process, as well as the risks and benefits of the treatment options. Biomarkers to guide patient selection in clinical trials for new treatments were incorporated into the algorithm.

Results

The a

SUBMITTER: Black PC 

PROVIDER: S-EPMC7402696 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature