Comprehensive analysis of RNA binding motif protein 3 (RBM3) in non-small cell lung cancer.

ABSTRACT:

Aims

High expression of the RNA-binding motif protein 3 (RBM3) correlates with improved prognosis in several major types of cancer. The aim of the present study was to examine the prognostic value of RBM3 protein and mRNA expression in non-small cell lung cancer (NSCLC).

Methods and results

Immunohistochemical expression of RBM3 was evaluated in surgically treated NSCLC from two independent patient populations (n = 213 and n = 306). Staining patterns were correlated with clinicopathological parameters, overall survival (OS), and recurrence-free interval (RFI). Cases with high nuclear RBM3 protein expression had a prolonged 5-year OS in both cohorts when analyzing adenocarcinomas separately (P = .02 and P = .01). RBM3 remained an independent prognostic factor for OS in multiv

SUBMITTER: Salomonsson A 

PROVIDER: S-EPMC7402820 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature