Galangin promotes cell apoptosis through suppression of H19 expression in hepatocellular carcinoma cells.

ABSTRACT:

Background

Galangin has been extensively studied as the antitumor agent in various cancers. However, the effect of galangin in hepatocellular carcinoma (HCC) remains elusive.

Methods

Using RNA sequencing, the differential expression of lncRNA in human HCC cell line with highly metastatic potential (MHCC97H) cells treated with galangin was investigated. Furthermore, H19 expression pattern was also determined in MHCC97H cells following treatment with galangin. In addition, knockdown and overexpression of H19 was performed to analyze the effect of the expression pattern of H19 on cell apoptosis, cell cycle, migration, and invasion in HCC cells. Moreover, the in vivo effect of galangin on tumor development was also determined in nude mice. In order to analyze loss expression of

SUBMITTER: Zhong X 

PROVIDER: S-EPMC7402821 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature