Gene Expression Profile of Isolated Dermal Vascular Endothelial Cells in Keloids.

ABSTRACT: Wound healing is a complex biological process, and imbalances of various substances in the wound environment may prolong healing and lead to excessive scarring. Keloid is abnormal proliferation of scar tissue beyond the original wound margins with excessive deposition of extracellular matrix (ECM) and chronic inflammation. Despite numerous previous research efforts, the pathogenesis of keloid remains unknown. Vascular endothelial cells (VECs) are a major type of inductive cell in inflammation and fibrosis. Despite several studies on vascular morphology in keloid formation, there has been no functional analysis of the role of VECs. In the present study, we isolated living VECs from keloid tissues and investigated gene expression patterns using microarray analysis. We obtained 5 keloid tissu

SUBMITTER: Matsumoto NM 

PROVIDER: S-EPMC7403211 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature