A Single Dose of NILV-Based Vaccine Provides Rapid and Durable Protection against Zika Virus.

ABSTRACT: Zika virus, a member of the Flaviviridae family, is primarily transmitted by infected Aedes species mosquitoes. In 2016, Zika infection emerged as a global health emergency for its explosive spread and the remarkable neurological defects in the developing fetus. Development of a safe and effective Zika vaccine remains a high priority owing to the risk of re-emergence and limited understanding of Zika virus epidemiology. We engineered a non-integrating lentiviralvector(NILV)-based Zika vaccine encoding the consensus pre-membrane and envelope glycoprotein of circulating Zika virus strains. We further evaluated the immunogenicity and protective efficacy of this vaccine in both immunocompromised and immunocompetent mouse models. A single immunization in both mouse models elicited a robust neut

SUBMITTER: Ku MW 

PROVIDER: S-EPMC7403329 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature