Identification of EMT-related high-risk stage II colorectal cancer and characterisation of metastasis-related genes.

ABSTRACT:

Background

Our laboratory previously reported an individual-level prognostic signature for patients with stage II colorectal cancer (CRC). However, this signature was not applicable for RNA-sequencing datasets. In this study, we constructed a robust epithelial-to-mesenchymal transition (EMT)- related gene pair prognostic signature.

Methods

Based on EMT-related genes, metastasis-associated gene pairs were identified between metastatic and non-metastatic samples. Then, we selected prognosis-associated gene pairs, which were significantly correlated with disease-free survival of stage II CRC using multivariate Cox regression model, as the EMT-related prognosis signature.

Results

An EMT-related signature composed of fifty-one gene pairs (51-GPS) for prediction-relapse ris

SUBMITTER: Wang K 

PROVIDER: S-EPMC7403418 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature