Knockdown of CYP24A1 Aggravates 1α,25(OH)₂D₃-Inhibited Migration and Invasion of Mouse Ovarian Epithelial Cells by Suppressing EMT.

ABSTRACT: Epithelial-mesenchymal transition (EMT) bestows cancer cells with motile and invasive properties. But for ovarian tissues, EMT plays a physiological role in the postovulatory repair of ovary surface epithelial (OSE) cells. Accumulating data indicated that 1α,25(OH)₂D₃ decreased both the migration and invasion of various cancer cells by suppressing EMT. However, it remains unclear whether 1α,25(OH)₂D₃ inhibits the process of EMT during different stages of oncogenic transformation in mouse OSE (MOSE) cells. In present study, a spontaneous malignant transformation model of MOSE cells at three sequential stages (early, intermediate and late) was established in vitro first and then subjected to 1α,25(OH)₂D₃ treatment to in

SUBMITTER: Wang P 

PROVIDER: S-EPMC7403498 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature