Elaboration of the Corticosteroid Synthesis Pathway in Primates through a Multistep Enzyme.

ABSTRACT: Metabolic networks are complex cellular systems dependent on the interactions among, and regulation of, the enzymes in the network. Although there is great diversity of types of enzymes that make up metabolic networks, the models meant to understand the possible evolutionary outcomes following duplication neglect specifics about the enzyme, pathway context, and cellular constraints. To illuminate the mechanisms that shape the evolution of biochemical pathways, I functionally characterize the consequences of gene duplication of an enzyme family that performs multiple subsequent enzymatic reactions (a multistep enzyme) in the corticosteroid pathway in primates. The products of the corticosteroid pathway (aldosterone and cortisol) are steroid hormones that regulate metabolism and stress respo

SUBMITTER: Olson-Manning CF 

PROVIDER: S-EPMC7403617 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature