Single-Nephron GFR in Patients With Obesity-Related Glomerulopathy.

ABSTRACT:

Introduction

Obesity-related glomerulopathy (ORG) is a slowly progressive kidney disease occurring in association with obesity. It is characterized histopathologically by glomerulomegaly, likely caused by single-nephron hyperfiltration that has not been demonstrated in humans because of technical difficulty in measuring single-nephron glomerular filtration rate (SNGFR) in the clinical setting.

Methods

Total glomerular number per kidney, with or without global glomerulosclerosis, was estimated by the combination of cortical volume assessment via unenhanced computed tomography and biopsy-based stereology. Mean glomerular volume was calculated from the measured area of glomerular tufts. Both SNGFR and single-nephron urinary protein excretion (SNUPE) were estimated by dividing v

SUBMITTER: Okabayashi Y 

PROVIDER: S-EPMC7403629 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature