Identification of the association between HMMR expression and progression of hepatocellular carcinoma via construction of a co-expression network.

ABSTRACT: The aim of the present study was to identify key genes involved in the progression of hepatocellular carcinoma (HCC). According to the theory of the multistep process of hepatocarcinogenesis and weighted gene co-expression network analysis, hub genes associated with the progression of HCC were identified using the gene expression profiles of patients with normal to chronic hepatitis/cirrhosis and dysplastic nodules to HCC. An independent dataset was used to verify the association between hub gene and clinical phenotype. The diagnostic and prognostic value of hub genes regarding HCC were evaluated. Gene set enrichment analysis (GSEA) was performed to explore the function of hub genes. A co-expression gene module positively associated with HCC progression was identified. Combined with a prot

SUBMITTER: Lu D 

PROVIDER: S-EPMC7403633 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature