Association between herpes simplex virus 1 exposure and the risk of depression in UK Biobank.

ABSTRACT:

Background

Herpes simplex virus-1 (HSV-1) infection is reported to be associated with depression. But limited efforts were made to investigate the relationship between HSV-1 infection and the risk of depression, especially from the genetic perspective.

Methods

In UK Biobank cohort, linear and logistic regression analyses were first performed to test the association of HSV-1 seropositivity/antibody with depression, including depression status (N = 2951) and Patient Health Questionnaire (PHQ) score (N = 2839). Using individual genotypic and phenotypic data from the UK Biobank, genome-wide environmental interaction study (GWEIS) was then conducted by PLINK2.0 to evaluate gene × HSV-1 interacting effect on the risk of depression. Finally, gene set enrichment analysis was conduct

SUBMITTER: Ye J 

PROVIDER: S-EPMC7403656 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature