Evidence for endothelial-to-mesenchymal transition in human brain arteriovenous malformations.

ABSTRACT:

Background

Brain arteriovenous malformations (AVMs) are rare, potentially devastating cerebrovascular lesions that can occur in both children and adults. AVMs are largely sporadic and the basic disease biology remains unclear, limiting advances in both detection and treatment. This study aimed to investigate human brain AVMs for endothelial-to-mesenchymal transition (EndMT), a process recently implicated in cerebral cavernous malformations (CCMs).

Methods

We used 29 paraffin-embedded and 13 fresh/frozen human brain AVM samples to profile expression of panels of EndMT-associated proteins and RNAs. CCMs, a cerebrovascular disease also characterized by abnormal vasculature, were used as a primary comparison, given that EndMT specifically contributes to CCM disease biology. AVM-

SUBMITTER: Shoemaker LD 

PROVIDER: S-EPMC7403663 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature