Proteomic analysis enables distinction of early- versus advanced-stage lung adenocarcinomas.

ABSTRACT:

Background

A gel-free proteomic approach was utilized to perform in-depth tissue protein profiling of lung adenocarcinoma (ADC) and normal lung tissues from early and advanced stages of the disease. The long-term goal of this study is to generate a large-scale, label-free proteomics dataset from histologically well-classified lung ADC that can be used to increase further our understanding of disease progression and aid in identifying novel biomarkers.

Methods and results

Cases of early-stage (I-II) and advanced-stage (III-IV) lung ADCs were selected and paired with normal lung tissues from 22 patients. The histologically and clinically stratified human primary lung ADCs were analyzed by liquid chromatography-tandem mass spectrometry. From the analysis of ADC and normal speci

SUBMITTER: Kelemen O 

PROVIDER: S-EPMC7403673 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature