T-cell activation and immune memory enhancement induced by irreversible electroporation in pancreatic cancer.

ABSTRACT:

Background

Irreversible electroporation is shown to induce immune changes in pancreatic cancer while the histology evidences are still lacking. The aim of this study is to show the immune changes in histology and explore whether irreversible electroporation (IRE) can induce immunogenic cell death (ICD) of tumor cells and activate specific immune responses.

Methods

Subcutaneous and orthotopic pancreatic cancer models were established and used to evaluate the effect of immune modulation of IRE. The infiltration of T cells was assessed in several tissue samples before and after IRE. Abscopal effect was then assessed by comparing the tumor growth of subcutaneous tumors after in situ ablation with IRE or exposure to tumor culture supernatant (TSN) of IRE-treated Pan02. The expres

SUBMITTER: He C 

PROVIDER: S-EPMC7403705 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature