Clinicopathological characteristics of breast cancer patients with NOD2 mutation according to age.

ABSTRACT:

Introduction

The purpose of the present study was to characterise patients with breast cancer (BC) and NOD2-mutation (age ≥ 50 years) according to their clinicopathological factors or family history. Patients aged ≥ 50 years were compared with the control group and with NOD2-mutation carriers aged < 50 years.

Material and methods

Prognostic factors were analysed in patients with BC with confirmed NOD2 c.3016_3017insC (n = 150) mutations. The control group was selected from patients with BC without mutations (n = 376).

Results

There were significant differences between NOD2-mutation carriers and the control group aged ≥ 50 years, according to HER2 overexpression (p = 0.0001), ER (-) (p = 0.007), PR (-) (p =

SUBMITTER: Huszno J 

PROVIDER: S-EPMC7403763 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature