Semantic loss marks early Alzheimer's disease-related neurodegeneration in older adults without dementia.

ABSTRACT:

Objective

To assess progression of semantic loss in early stages of cognitive decline using semantic and letter fluency performance, and its relation with Alzheimer's disease (AD)-specific neurodegeneration using longitudinal multimodal neuroimaging measures.

Methods

Change in verbal fluency was analyzed among 2261 non-demented individuals with a follow-up diagnosis of no mild cognitive impairment (MCI), amnestic MCI (aMCI), non-amnestic MCI (naMCI), or incident dementia, using linear mixed models across 4 years of follow-up, and relations with magnetic resonance imaging (MRI; n = 1536) and ¹⁸F-fluorodeoxyglucose brain positron emission tomography (¹⁸F-FDG-PET) imaging (n = 756) using linear regression models across 2 years of follow-up.

Results

SUBMITTER: Vonk JMJ 

PROVIDER: S-EPMC7403823 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature