Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population.

ABSTRACT:

Introduction

Dozens of Alzheimer's disease (AD)-associated loci have been identified in European-descent populations, but their effects have not been thoroughly investigated in the Hong Kong Chinese population.

Methods

TaqMan array genotyping was performed for known AD-associated variants in a Hong Kong Chinese cohort. Regression analysis was conducted to study the associations of variants with AD-associated traits and biomarkers. Lasso regression was applied to establish a polygenic risk score (PRS) model for AD risk prediction.

Results

SORL1 is associated with AD in the Hong Kong Chinese population. Meta-analysis corroborates the AD-protective effect of the SORL1 rs11218343 C allele. The PRS is developed and associated with AD risk, cognitive status, a

SUBMITTER: Zhou X 

PROVIDER: S-EPMC7403835 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature