Selectively-Packaged Proteins in Breast Cancer Extracellular Vesicles Involved in Metastasis.

ABSTRACT: Cancer-derived extracellular vesicles are known to play a role in the progression of the disease. In this rapidly-growing field, there are many reports of phenotypic changes in cells following exposure to cancer-derived extracellular vesicles. This study examines the protein contents of vesicles derived from three well-known breast cancer cell lines, MCF-7, MDA-MB-231 and T47D, using peptide-centric LC-MS/MS and cytokine multiplex immunoassay analysis to understand the molecular basis of these changes. Through these techniques a large number of proteins within these vesicles were identified. A large proportion of these proteins are known to be important in cancer formation and progression and associated with cancer signaling, angiogenesis, metastasis and invasion and immune regulation. Thi

SUBMITTER: Dalla PV 

PROVIDER: S-EPMC7403963 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature