Crosstalk of Brain and Bone-Clinical Observations and Their Molecular Bases.

ABSTRACT: As brain and bone disorders represent major health issues worldwide, substantial clinical investigations demonstrated a bidirectional crosstalk on several levels, mechanistically linking both apparently unrelated organs. While multiple stress, mood and neurodegenerative brain disorders are associated with osteoporosis, rare genetic skeletal diseases display impaired brain development and function. Along with brain and bone pathologies, particularly trauma events highlight the strong interaction of both organs. This review summarizes clinical and experimental observations reported for the crosstalk of brain and bone, followed by a detailed overview of their molecular bases. While brain-derived molecules affecting bone include central regulators, transmitters of the sympathetic, parasympathe

SUBMITTER: Otto E 

PROVIDER: S-EPMC7404044 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature