Long-Term Impact of Early-Life Stress on Hippocampal Plasticity: Spotlight on Astrocytes.

ABSTRACT: Adverse experiences during childhood are among the most prominent risk factors for developing mood and anxiety disorders later in life. Early-life stress interventions have been established as suitable models to study the neurobiological basis of childhood adversity in rodents. Different models such as maternal separation, impaired maternal care and juvenile stress during the postweaning/prepubertal life phase are utilized. Especially within the limbic system, they induce lasting alterations in neuronal circuits, neurotransmitter systems, neuronal architecture and plasticity that are further associated with emotional and cognitive information processing. Recent studies found that astrocytes, a special group of glial cells, have altered functions following early-life stress as well. As part

SUBMITTER: Calıskan G 

PROVIDER: S-EPMC7404101 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature