Biodistribution PET/CT Study of Hemoglobin-DFO-⁸⁹Zr Complex in Healthy and Lung Tumor-Bearing Mice.

ABSTRACT: Proteins, as a major component of organisms, are considered the preferred biomaterials for drug delivery vehicles. Hemoglobin (Hb) has been recently rediscovered as a potential drug carrier, but its use for biomedical applications still lacks extensive investigation. To further explore the possibility of utilizing Hb as a potential tumor targeting drug carrier, we examined and compared the biodistribution of Hb in healthy and lung tumor-bearing mice, using for the first time ⁸⁹Zr labelled Hb in a positron emission tomography (PET) measurement. Hb displays a very high conjugation yield in its fast and selective reaction with the maleimide-deferoxamine (DFO) bifunctional chelator. The high-resolution X-ray structure of the Hb-DFO complex demonstrated that cysteine β93 is the sole

SUBMITTER: Kiraga L 

PROVIDER: S-EPMC7404105 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature