Irinotecan-Still an Important Player in Cancer Chemotherapy: A Comprehensive Overview.

ABSTRACT: Irinotecan has been used in the treatment of various malignancies for many years. Still, the knowledge regarding this drug is expanding. The pharmacogenetics of the drug is the crucial component of response to irinotecan. Furthermore, new formulations of the drug are introduced in order to better deliver the drug and avoid potentially life-threatening side effects. Here, we give a comprehensive overview on irinotecan's molecular mode of action, metabolism, pharmacogenetics, and toxicity. Moreover, this article features clinically used combinations of the drug with other anticancer agents and introduces novel formulations of drugs (e.g., liposomal formulations, dendrimers, and nanoparticles). It also outlines crucial mechanisms of tumor cells' resistance to the active metabolite, ethyl-10-h

SUBMITTER: Kciuk M 

PROVIDER: S-EPMC7404108 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature