Seeding and Growth of β-Amyloid Aggregates upon Interaction with Neuronal Cell Membranes.

ABSTRACT: In recent years, the prevalence of amyloid neurodegenerative diseases such as Alzheimer's disease (AD) has significantly increased in developed countries due to increased life expectancy. This amyloid disease is characterized by the presence of accumulations and deposits of β-amyloid peptide (Aβ) in neuronal tissue, leading to the formation of oligomers, fibers, and plaques. First, oligomeric intermediates that arise during the aggregation process are currently thought to be primarily responsible for cytotoxicity in cells. This work aims to provide further insights into the mechanisms of cytotoxicity by studying the interaction of Aβ aggregates with Neuro-2a (N2a) neuronal cells and the effects caused by this interaction. For this purpose, we have exploited the advantages of advanced, mult

SUBMITTER: Ruiz-Arias A 

PROVIDER: S-EPMC7404110 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature