Therapeutic Potentials of Extracellular Vesicles for the Treatment of Diabetes and Diabetic Complications.

ABSTRACT: Extracellular vesicles (EVs), including exosomes and microvesicles, are nano-to-micrometer vesicles released from nearly all cellular types. EVs comprise a mixture of bioactive molecules (e.g., mRNAs, miRNAs, lipids, and proteins) that can be transported to the targeted cells/tissues via the blood or lymph circulation. Recently, EVs have received increased attention, owing to their emerging roles in cell-to-cell communication, or as biomarkers with the therapeutic potential to replace cell-based therapy. Diabetes comprises a group of metabolic disorders characterized by hyperglycemia that cause the development of life-threatening complications. The impacts of conventional clinical treatment are generally limited and are followed by many side effects, including hypoglycemia, obesity, and da

SUBMITTER: Hu W 

PROVIDER: S-EPMC7404127 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature