Ontology highlight
ABSTRACT:
SUBMITTER: Wei Q
PROVIDER: S-EPMC7404154 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Wei Qiang Q Holle Andrew A Li Jie J Posa Francesca F Biagioni Francesca F Croci Ottavio O Benk Amelie S AS Young Jennifer J Noureddine Fatima F Deng Jie J Zhang Man M Inman Gareth J GJ Spatz Joachim P JP Campaner Stefano S Cavalcanti-Adam Elisabetta A EA
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20200616 15
Growth factors and mechanical cues synergistically affect cellular functions, triggering a variety of signaling pathways. The molecular levels of such cooperative interactions are not fully understood. Due to its role in osteogenesis, the growth factor bone morphogenetic protein 2 (BMP-2) is of tremendous interest for bone regenerative medicine, osteoporosis therapeutics, and beyond. Here, contribution of BMP-2 signaling and extracellular mechanical cues to the osteogenic commitment of C2C12 cel ...[more]