Biodegradable Magnesium Alloys Promote Angio-Osteogenesis to Enhance Bone Repair.

ABSTRACT: Biodegradable metallic materials represent a potential step-change technology that may revolutionize the treatment of broken bones. Implants made with biodegradable metals are significantly stronger than their polymer counterparts and fully biodegradable in vivo, removing the need for secondary surgery or long-term complications. Here, it is shown how clinically approved Mg alloy promotes improved bone repair using an integrated state of the art fetal mouse metatarsal assay coupled with in vivo preclinical studies, second harmonic generation, secretome array analysis, perfusion bioreactor, and high-resolution 3D confocal imaging of vasculature within skeletal tissue, to reveal a vascular-mediated pro-osteogenic mechanism controlling enhanced tissue regeneration. The optimized mechanical pr

SUBMITTER: Han HS 

PROVIDER: S-EPMC7404158 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature