The Role of Tricellulin in Epithelial Jamming and Unjamming via Segmentation of Tricellular Junctions.

ABSTRACT: Collective cellular behavior in confluent monolayers supports physiological and pathological processes of epithelial development, regeneration, and carcinogenesis. Here, the attainment of a mature and static tissue configuration or the local reactivation of cell motility involve a dynamic regulation of the junctions established between neighboring cells. Tricellular junctions (tTJs), established at vertexes where three cells meet, are ideally located to control cellular shape and coordinate multicellular movements. However, their function in epithelial tissue dynamic remains poorly defined. To investigate the role of tTJs establishment and maturation in the jamming and unjamming transitions of epithelial monolayers, a semi-automatic image-processing pipeline is developed and validated enab

SUBMITTER: Lohmann S 

PROVIDER: S-EPMC7404176 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature